PoplarV1, Main, Exploration, bibRecord, 000E65

Genome-wide association studies and expression-based quantitative trait loci analyses reveal roles of HCT2 in caffeoylquinic acid biosynthesis and its regulation by defense-responsive transcription factors in Populus.

Identifieur interne : 000E65 ( Main/Exploration ); précédent : 000E64; suivant : 000E66

Genome-wide association studies and expression-based quantitative trait loci analyses reveal roles of HCT2 in caffeoylquinic acid biosynthesis and its regulation by defense-responsive transcription factors in Populus.

Auteurs : Jin Zhang [États-Unis] ; Yongil Yang [États-Unis] ; Kaijie Zheng [États-Unis] ; Meng Xie [États-Unis] ; Kai Feng [États-Unis] ; Sara S. Jawdy [États-Unis] ; Lee E. Gunter [États-Unis] ; Priya Ranjan [États-Unis] ; Vasanth R. Singan [États-Unis] ; Nancy Engle [États-Unis] ; Erika Lindquist [États-Unis] ; Kerrie Barry [États-Unis] ; Jeremy Schmutz [États-Unis] ; Nan Zhao [États-Unis] ; Timothy J. Tschaplinski [États-Unis] ; Jared Leboldus [États-Unis] ; Gerald A. Tuskan [États-Unis] ; Jin-Gui Chen [États-Unis] ; Wellington Muchero [États-Unis]

Source :

The New phytologist [ 1469-8137 ] ; 2018.

RBID : pubmed:29992670

Descripteurs français

KwdFr :
- Acide quinique (analogues et dérivés), Acide quinique (métabolisme), Domaine catalytique (MeSH), Duplication de gène (MeSH), Facteurs de transcription (métabolisme), Locus de caractère quantitatif (génétique), Métabolome (MeSH), Polymorphisme de nucléotide simple (génétique), Populus (génétique), Protéines végétales (composition chimique), Protéines végétales (métabolisme), Régulation de l'expression des gènes végétaux (MeSH), Réseaux de régulation génique (MeSH), Séquence d'acides aminés (MeSH), Étude d'association pangénomique (MeSH).
MESH :
- analogues et dérivés : Acide quinique.
- composition chimique : Protéines végétales.
- génétique : Locus de caractère quantitatif, Polymorphisme de nucléotide simple, Populus.
- métabolisme : Acide quinique, Facteurs de transcription, Protéines végétales.
- Domaine catalytique, Duplication de gène, Métabolome, Régulation de l'expression des gènes végétaux, Réseaux de régulation génique, Séquence d'acides aminés, Étude d'association pangénomique.

English descriptors

KwdEn :
- Amino Acid Sequence (MeSH), Catalytic Domain (MeSH), Gene Duplication (MeSH), Gene Expression Regulation, Plant (MeSH), Gene Regulatory Networks (MeSH), Genome-Wide Association Study (MeSH), Metabolome (MeSH), Plant Proteins (chemistry), Plant Proteins (metabolism), Polymorphism, Single Nucleotide (genetics), Populus (genetics), Quantitative Trait Loci (genetics), Quinic Acid (analogs & derivatives), Quinic Acid (metabolism), Transcription Factors (metabolism).
MESH :
- chemical , analogs & derivatives : Quinic Acid.
- chemical , chemistry : Plant Proteins.
- chemical , metabolism : Plant Proteins, Quinic Acid, Transcription Factors.
- genetics : Polymorphism, Single Nucleotide, Populus, Quantitative Trait Loci.
- Amino Acid Sequence, Catalytic Domain, Gene Duplication, Gene Expression Regulation, Plant, Gene Regulatory Networks, Genome-Wide Association Study, Metabolome.

Abstract

3-O-caffeoylquinic acid, also known as chlorogenic acid (CGA), functions as an intermediate in lignin biosynthesis in the phenylpropanoid pathway. It is widely distributed among numerous plant species and acts as an antioxidant in both plants and animals. Using GC-MS, we discovered consistent and extreme variation in CGA content across a population of 739 4-yr-old Populus trichocarpa accessions. We performed genome-wide association studies (GWAS) from 917 P. trichocarpa accessions and expression-based quantitative trait loci (eQTL) analyses to identify key regulators. The GWAS and eQTL analyses resolved an overlapped interval encompassing a hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transferase 2 (PtHCT2) that was significantly associated with CGA and partially characterized metabolite abundances. PtHCT2 leaf expression was significantly correlated with CGA abundance and it was regulated by cis-eQTLs containing W-box for WRKY binding. Among all nine PtHCT homologs, PtHCT2 is the only one that responds to infection by the fungal pathogen Sphaerulina musiva (a Populus pathogen). Validation using protoplast-based transient expression system suggests that PtHCT2 is regulated by the defense-responsive WRKY. These results are consistent with reports of CGA functioning as an antioxidant in response to biotic stress. This study provides insights into data-driven and omics-based inference of gene function in woody species.

DOI: 10.1111/nph.15297
PubMed: 29992670

Affiliations:

États-Unis

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Le document en format XML

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<author><name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name>
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<author><name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name>
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<author><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide association studies and expression-based quantitative trait loci analyses reveal roles of HCT2 in caffeoylquinic acid biosynthesis and its regulation by defense-responsive transcription factors in Populus.</title>
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<author><name sortKey="Yang, Yongil" sort="Yang, Yongil" uniqKey="Yang Y" first="Yongil" last="Yang">Yongil Yang</name>
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<author><name sortKey="Gunter, Lee E" sort="Gunter, Lee E" uniqKey="Gunter L" first="Lee E" last="Gunter">Lee E. Gunter</name>
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<author><name sortKey="Singan, Vasanth R" sort="Singan, Vasanth R" uniqKey="Singan V" first="Vasanth R" last="Singan">Vasanth R. Singan</name>
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<author><name sortKey="Engle, Nancy" sort="Engle, Nancy" uniqKey="Engle N" first="Nancy" last="Engle">Nancy Engle</name>
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<author><name sortKey="Lindquist, Erika" sort="Lindquist, Erika" uniqKey="Lindquist E" first="Erika" last="Lindquist">Erika Lindquist</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>US Department of Energy Joint Genome Institute, Walnut Creek, CA, 94598</wicri:regionArea>
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<author><name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Agriculture, University of Tennessee, Knoxville, TN, 37996</wicri:regionArea>
<wicri:noRegion>37996</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tschaplinski, Timothy J" sort="Tschaplinski, Timothy J" uniqKey="Tschaplinski T" first="Timothy J" last="Tschaplinski">Timothy J. Tschaplinski</name>
<affiliation wicri:level="1"><nlm:affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831</wicri:regionArea>
<wicri:noRegion>37831</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leboldus, Jared" sort="Leboldus, Jared" uniqKey="Leboldus J" first="Jared" last="Leboldus">Jared Leboldus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, 97331, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, 97331</wicri:regionArea>
<wicri:noRegion>97331</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name>
<affiliation wicri:level="1"><nlm:affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831</wicri:regionArea>
<wicri:noRegion>37831</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831</wicri:regionArea>
<wicri:noRegion>37831</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muchero, Wellington" sort="Muchero, Wellington" uniqKey="Muchero W" first="Wellington" last="Muchero">Wellington Muchero</name>
<affiliation wicri:level="1"><nlm:affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831</wicri:regionArea>
<wicri:noRegion>37831</wicri:noRegion>
</affiliation>
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<series><title level="j">The New phytologist</title>
<idno type="eISSN">1469-8137</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term>
<term>Catalytic Domain (MeSH)</term>
<term>Gene Duplication (MeSH)</term>
<term>Gene Expression Regulation, Plant (MeSH)</term>
<term>Gene Regulatory Networks (MeSH)</term>
<term>Genome-Wide Association Study (MeSH)</term>
<term>Metabolome (MeSH)</term>
<term>Plant Proteins (chemistry)</term>
<term>Plant Proteins (metabolism)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Populus (genetics)</term>
<term>Quantitative Trait Loci (genetics)</term>
<term>Quinic Acid (analogs & derivatives)</term>
<term>Quinic Acid (metabolism)</term>
<term>Transcription Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide quinique (analogues et dérivés)</term>
<term>Acide quinique (métabolisme)</term>
<term>Domaine catalytique (MeSH)</term>
<term>Duplication de gène (MeSH)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Locus de caractère quantitatif (génétique)</term>
<term>Métabolome (MeSH)</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Populus (génétique)</term>
<term>Protéines végétales (composition chimique)</term>
<term>Protéines végétales (métabolisme)</term>
<term>Régulation de l'expression des gènes végétaux (MeSH)</term>
<term>Réseaux de régulation génique (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Étude d'association pangénomique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Quinic Acid</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Plant Proteins</term>
<term>Quinic Acid</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide quinique</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Polymorphism, Single Nucleotide</term>
<term>Populus</term>
<term>Quantitative Trait Loci</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Locus de caractère quantitatif</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide quinique</term>
<term>Facteurs de transcription</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Catalytic Domain</term>
<term>Gene Duplication</term>
<term>Gene Expression Regulation, Plant</term>
<term>Gene Regulatory Networks</term>
<term>Genome-Wide Association Study</term>
<term>Metabolome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Domaine catalytique</term>
<term>Duplication de gène</term>
<term>Métabolome</term>
<term>Régulation de l'expression des gènes végétaux</term>
<term>Réseaux de régulation génique</term>
<term>Séquence d'acides aminés</term>
<term>Étude d'association pangénomique</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">3-O-caffeoylquinic acid, also known as chlorogenic acid (CGA), functions as an intermediate in lignin biosynthesis in the phenylpropanoid pathway. It is widely distributed among numerous plant species and acts as an antioxidant in both plants and animals. Using GC-MS, we discovered consistent and extreme variation in CGA content across a population of 739 4-yr-old Populus trichocarpa accessions. We performed genome-wide association studies (GWAS) from 917 P. trichocarpa accessions and expression-based quantitative trait loci (eQTL) analyses to identify key regulators. The GWAS and eQTL analyses resolved an overlapped interval encompassing a hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transferase 2 (PtHCT2) that was significantly associated with CGA and partially characterized metabolite abundances. PtHCT2 leaf expression was significantly correlated with CGA abundance and it was regulated by cis-eQTLs containing W-box for WRKY binding. Among all nine PtHCT homologs, PtHCT2 is the only one that responds to infection by the fungal pathogen Sphaerulina musiva (a Populus pathogen). Validation using protoplast-based transient expression system suggests that PtHCT2 is regulated by the defense-responsive WRKY. These results are consistent with reports of CGA functioning as an antioxidant in response to biotic stress. This study provides insights into data-driven and omics-based inference of gene function in woody species.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29992670</PMID>
<DateCompleted><Year>2019</Year>
<Month>10</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-8137</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>220</Volume>
<Issue>2</Issue>
<PubDate><Year>2018</Year>
<Month>10</Month>
</PubDate>
</JournalIssue>
<Title>The New phytologist</Title>
<ISOAbbreviation>New Phytol</ISOAbbreviation>
</Journal>
<ArticleTitle>Genome-wide association studies and expression-based quantitative trait loci analyses reveal roles of HCT2 in caffeoylquinic acid biosynthesis and its regulation by defense-responsive transcription factors in Populus.</ArticleTitle>
<Pagination><MedlinePgn>502-516</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/nph.15297</ELocationID>
<Abstract><AbstractText>3-O-caffeoylquinic acid, also known as chlorogenic acid (CGA), functions as an intermediate in lignin biosynthesis in the phenylpropanoid pathway. It is widely distributed among numerous plant species and acts as an antioxidant in both plants and animals. Using GC-MS, we discovered consistent and extreme variation in CGA content across a population of 739 4-yr-old Populus trichocarpa accessions. We performed genome-wide association studies (GWAS) from 917 P. trichocarpa accessions and expression-based quantitative trait loci (eQTL) analyses to identify key regulators. The GWAS and eQTL analyses resolved an overlapped interval encompassing a hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transferase 2 (PtHCT2) that was significantly associated with CGA and partially characterized metabolite abundances. PtHCT2 leaf expression was significantly correlated with CGA abundance and it was regulated by cis-eQTLs containing W-box for WRKY binding. Among all nine PtHCT homologs, PtHCT2 is the only one that responds to infection by the fungal pathogen Sphaerulina musiva (a Populus pathogen). Validation using protoplast-based transient expression system suggests that PtHCT2 is regulated by the defense-responsive WRKY. These results are consistent with reports of CGA functioning as an antioxidant in response to biotic stress. This study provides insights into data-driven and omics-based inference of gene function in woody species.</AbstractText>
<CopyrightInformation>No claim to original US government works New Phytologist © 2018 New Phytologist Trust.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Jin</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">0000-0002-8397-5078</Identifier>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Yongil</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Kaijie</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Meng</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Kai</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jawdy</LastName>
<ForeName>Sara S</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gunter</LastName>
<ForeName>Lee E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ranjan</LastName>
<ForeName>Priya</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Singan</LastName>
<ForeName>Vasanth R</ForeName>
<Initials>VR</Initials>
<AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA, 94598, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Engle</LastName>
<ForeName>Nancy</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lindquist</LastName>
<ForeName>Erika</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA, 94598, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barry</LastName>
<ForeName>Kerrie</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA, 94598, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schmutz</LastName>
<ForeName>Jeremy</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA, 94598, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>HudsonAlpha Institute for Biotechnology, Huntsville, AL, 35806, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Nan</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Institute of Agriculture, University of Tennessee, Knoxville, TN, 37996, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tschaplinski</LastName>
<ForeName>Timothy J</ForeName>
<Initials>TJ</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>LeBoldus</LastName>
<ForeName>Jared</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, 97331, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tuskan</LastName>
<ForeName>Gerald A</ForeName>
<Initials>GA</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Jin-Gui</ForeName>
<Initials>JG</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muchero</LastName>
<ForeName>Wellington</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Oak Ridge National Laboratory, Biosciences Division and Center for Bioenergy Innovation, Oak Ridge, TN, 37831, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>DE-AC05-00OR22725</GrantID>
<Agency>Oak Ridge National Laboratory</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>DE-AC02-05CH11231</GrantID>
<Agency>Office of Science</Agency>
<Country>International</Country>
</Grant>
<Grant><Agency>US Department of Energy</Agency>
<Country>International</Country>
</Grant>
<Grant><Agency>Center for Bioenergy Innovation (CBI)</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>07</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>New Phytol</MedlineTA>
<NlmUniqueID>9882884</NlmUniqueID>
<ISSNLinking>0028-646X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C472707">caffeoylquinic acid</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>058C04BGYI</RegistryNumber>
<NameOfSubstance UI="D011801">Quinic Acid</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020134" MajorTopicYN="N">Catalytic Domain</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020440" MajorTopicYN="N">Gene Duplication</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018506" MajorTopicYN="Y">Gene Expression Regulation, Plant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053263" MajorTopicYN="N">Gene Regulatory Networks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055106" MajorTopicYN="Y">Genome-Wide Association Study</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055442" MajorTopicYN="N">Metabolome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D040641" MajorTopicYN="N">Quantitative Trait Loci</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011801" MajorTopicYN="N">Quinic Acid</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Populus trichocarpa
</Keyword>
<Keyword MajorTopicYN="Y">WRKY</Keyword>
<Keyword MajorTopicYN="Y">expression quantitative trait loci (eQTLs)</Keyword>
<Keyword MajorTopicYN="Y">genome-wide association studies (GWAS)</Keyword>
<Keyword MajorTopicYN="Y">hydroxycinnamoyl-CoA</Keyword>
<Keyword MajorTopicYN="Y">metabolome</Keyword>
<Keyword MajorTopicYN="Y">shikimate hydroxycinnamoyl transferase (HCT)</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>01</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>05</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>7</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>10</Month>
<Day>2</Day>
<Hour>6</Hour>
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<Month>7</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</ArticleIdList>
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</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name>
</noRegion>
<name sortKey="Barry, Kerrie" sort="Barry, Kerrie" uniqKey="Barry K" first="Kerrie" last="Barry">Kerrie Barry</name>
<name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name>
<name sortKey="Engle, Nancy" sort="Engle, Nancy" uniqKey="Engle N" first="Nancy" last="Engle">Nancy Engle</name>
<name sortKey="Feng, Kai" sort="Feng, Kai" uniqKey="Feng K" first="Kai" last="Feng">Kai Feng</name>
<name sortKey="Gunter, Lee E" sort="Gunter, Lee E" uniqKey="Gunter L" first="Lee E" last="Gunter">Lee E. Gunter</name>
<name sortKey="Jawdy, Sara S" sort="Jawdy, Sara S" uniqKey="Jawdy S" first="Sara S" last="Jawdy">Sara S. Jawdy</name>
<name sortKey="Leboldus, Jared" sort="Leboldus, Jared" uniqKey="Leboldus J" first="Jared" last="Leboldus">Jared Leboldus</name>
<name sortKey="Lindquist, Erika" sort="Lindquist, Erika" uniqKey="Lindquist E" first="Erika" last="Lindquist">Erika Lindquist</name>
<name sortKey="Muchero, Wellington" sort="Muchero, Wellington" uniqKey="Muchero W" first="Wellington" last="Muchero">Wellington Muchero</name>
<name sortKey="Ranjan, Priya" sort="Ranjan, Priya" uniqKey="Ranjan P" first="Priya" last="Ranjan">Priya Ranjan</name>
<name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name>
<name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name>
<name sortKey="Singan, Vasanth R" sort="Singan, Vasanth R" uniqKey="Singan V" first="Vasanth R" last="Singan">Vasanth R. Singan</name>
<name sortKey="Tschaplinski, Timothy J" sort="Tschaplinski, Timothy J" uniqKey="Tschaplinski T" first="Timothy J" last="Tschaplinski">Timothy J. Tschaplinski</name>
<name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name>
<name sortKey="Xie, Meng" sort="Xie, Meng" uniqKey="Xie M" first="Meng" last="Xie">Meng Xie</name>
<name sortKey="Yang, Yongil" sort="Yang, Yongil" uniqKey="Yang Y" first="Yongil" last="Yang">Yongil Yang</name>
<name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name>
<name sortKey="Zheng, Kaijie" sort="Zheng, Kaijie" uniqKey="Zheng K" first="Kaijie" last="Zheng">Kaijie Zheng</name>
</country>
</tree>
</affiliations>
</record>

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Genome-wide association studies and expression-based quantitative trait loci analyses reveal roles of HCT2 in caffeoylquinic acid biosynthesis and its regulation by defense-responsive transcription factors in Populus.

Genome-wide association studies and expression-based quantitative trait loci analyses reveal roles of HCT2 in caffeoylquinic acid biosynthesis and its regulation by defense-responsive transcription factors in Populus.

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